Expression data from Ezh2-null erythrocyte/megakaryocyte progenitor (MEP)

The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through transcriptional repression of target genes. EZH2 is a catalytic component of PRC2 and trimethylates histone H3 at lysine 27 to transcriptionally repress the target genes. PcG proteins have been characterized as general regulators of stem cells, but recent works also unveiled their critical roles in cancer. Wild type and Ezh2 null MEP from fetal liver and adult bone marrow多梳蛋白家族（polycomb group, PcG）通过组蛋白修饰发挥基因沉默功能。它们可形成结合于染色质的多蛋白复合物，即多梳抑制复合物1（polycomb repressive complex 1, PRC1）与PRC2。这两类复合物通过对靶基因的转录抑制协同维持细胞记忆。EZH2是PRC2的催化亚基，可对组蛋白H3第27位赖氨酸进行三甲基化修饰，从而转录抑制靶基因。多梳蛋白家族曾被认为是干细胞的通用调控因子，而近期研究揭示了其在癌症中的关键作用。本数据集包含来自胎肝与成年骨髓的野生型及Ezh2基因敲除的MEP细胞。