FOXP2 expression was decreased in placental tissue sample of patients with preeclampsia compared with healthy pregnant women

Preeclampsia (PE) is a common pregnancy disorder, and it complicates 5~7% of all pregnancies. At present, termination of pregnancy is the only curative strategy for PE. To explore a potential target for PE treatment, we collected placental tissue samples from patients with preeclampsia (PE) and normal pregnant women (N), and performed high-throughput RNA sequencing. We found that FOXP2 was significantly downregulated in placental samples of patients with PE compared with the controls. In the present study, placental tissue samples were collected from patients with PE (n = 6) and normal pregnant women (n = 6) and used for high-throughput RNA-sequencing to analyze gene expression profiles.