PopHuman

PopHuman is a population genomics-oriented genome browser based on JBrowse that allows the interactive visualization and retrieval of an extensive inventory of population genetics metrics. Efficient and reliable parameter estimates have been computed using a novel pipeline that faces the unique features and limitations of the 1000GP data, and include a battery of nucleotide variation measures, divergence and linkage disequilibrium parameters, as well as different tests of neutrality, estimated in non-overlapping windows along the chromosomes and in annotated genes for all 26 populations of the 1000GP.PopHuman是一款面向群体基因组学的基因组浏览器，基于JBrowse开发，可实现大规模群体遗传学指标集的交互式可视化与检索。本工具通过全新分析流程完成高效可靠的参数估计，该流程适配了千人基因组计划（1000GP）数据的独特特征与局限性。其所涵盖的指标包括一系列核苷酸变异度量、分化与连锁不平衡（linkage disequilibrium）参数，以及多种中性检验指标，上述指标均在1000GP全部26个人群的染色体非重叠窗口及注释基因中完成估算。

搜集汇总

背景与挑战

背景概述

PopHuman是一个基于JBrowse的人类群体基因组学浏览器，整合了千人基因组计划（1000GP）的数据。它提供了包括核苷酸多样性、连锁不平衡、重组率和中性检验在内的多种群体遗传学指标，覆盖了26个人类群体，支持交互式可视化与检索。