DCABM-TCM: A Database of Constituents Absorbed into the Blood and Metabolites of Traditional Chinese Medicine

Traditional Chinese
medicine (TCM) not only maintains the health
of Asian people but also provides a great resource of active natural
products for modern drug development. Herein, we developed a Database
of Constituents Absorbed into the Blood and Metabolites of TCM (DCABM-TCM),
the first database systematically collecting blood constituents of
TCM prescriptions and herbs, including prototypes and metabolites
experimentally detected in the blood, together with the corresponding
detailed detection conditions through manual literature mining. The
DCABM-TCM has collected 1816 blood constituents with chemical structures
of 192 prescriptions and 194 herbs and integrated their related annotations,
including physicochemical, absorption, distribution, metabolism, excretion,
and toxicity properties, and associated targets, pathways, and diseases.
Furthermore, the DCABM-TCM supported two blood constituent-based analysis
functions, the network pharmacology analysis for TCM molecular mechanism
elucidation, and the target/pathway/disease-based screening of candidate
blood constituents, herbs, or prescriptions for TCM-based drug discovery.
The DCABM-TCM is freely accessible at http://bionet.ncpsb.org.cn/dcabm-tcm/. The DCABM-TCM will contribute to the elucidation of effective constituents
and molecular mechanism of TCMs and the discovery of TCM-derived drug-like
compounds that are both bioactive and bioavailable.