TAF1 is critical for AE driven leukemogenesis [RNA-seq]

TAF1 is essential for AE driven leukemogenesis. Depletion of TAF1 impairs the recruitment of AE to its target genes, interfering with its control of gene expression. The bromodomains of TAF1 associate with K43 acetylated AE and this association plays a role in the proliferation of AE expressing AML cells. RNAseq of total RNA collected from Kasumi-1 acute myeloid leukemia cells after targeting TAF1 with lentiviral knockdown or with inhibitor.