Transcriptome characterization of patient-derived xenografts and cancer cell lines from nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is rare worldwide but common in southern China, including Hong Kong. The lack of representative NPC models has hampered research in the carcinogenesis and preclinical studies in NPC. We have recently established four patient-derived xenografts (PDXs) and three cancer cell lines from NPC tissues. Their genetic background has well characterized using genomic next-generation sequencing. To further delineate the transcriptome profiles of these newly established PDXs and cell lines, and further comprehensively compare the transcriptome differences between Epstein-Barr virus (EBV)-positive and –negative NPC, we performed RNA sequencing to determine the gene expression levels.