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Table S3 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction

Figshare2020-04-01 更新2026-04-28 收录

CAR-NKT细胞疗法

T细胞耗竭

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https://figshare.com/articles/dataset/Table_S3_from_Impaired_Death_Receptor_Signaling_in_Leukemia_Causes_Antigen-Independent_Resistance_by_Inducing_CAR_T-cell_Dysfunction/22535471 数据链接链接失效反馈

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Genes used to define exhaustion

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创建时间：

2020-04-01

肿瘤免疫治疗

T细胞耗竭

VEGF-A drives TOX-dependent T cell exhaustion in anti–PD-1–resistant microsatellite stable colorectal cancers Overall design: Normal colon, MC38-OVA, Control siRNA transfected, TOX siRNA transfected C

NIAID Data Ecosystem80

RNA-Seq analysis of P14 CD8+T cells in B16-GP tumors

肿瘤浸润T细胞

T细胞耗竭

CD8+ T cells play an important role in fighting against tumors. However, CD8+ T cells often become functionally impaired or “exhausted” in the tumor microenvironment. T cell exhaustion is a major hurd

NIAID Data Ecosystem60

Homo sapiens Transcriptome or Gene expression

CAR-NKT细胞疗法

实体瘤靶向治疗

The clinical application of chimeric antigen receptor (CAR) T cell therapy in solid tumors remains limited due to significant safety concerns, particularly "on-target, off-tumor" toxicity and cytokine

NIAID Data Ecosystem30

Supplementary Material for: Recapitulated late-onset inflammatory toxicities and progressive dysautonomia with persistence of central memory CD4+ chimeric antigen receptor T cells in a case of transformed follicular lymphoma: case report

CAR-NKT细胞疗法

免疫毒性

CD19-directed chimeric antigen receptor (CAR) T-cell therapy has been widely used and highly effective for B-cell lymphoid malignancies. Immune-mediated adverse effects such as cytokine release syndro

DataCite Commons2023-04-21 更新80

scRNA-seq of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice

肿瘤免疫

T细胞耗竭

CD8+ T cell-mediated immune response plays a pivotal role in controlling tumor growth.However, within the tumor microenvironment (TME), prolonged antigen exposure, as well as immunosuppressive factors

NIAID Data Ecosystem60

Table S3 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction

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