Transcriptome analysis of pineal glands in a mouse model of Alzheimer's disease

The pineal gland maintains the circadian rhythm in the body by secreting the hormone melatonin. Alzheimer's disease (AD) is the most common neurodegenerative disease. Pineal gland impairment in AD is widely observed, but no study to date has analyzed the transcriptome in the pineal glands of AD. To establish resources for the study on pineal gland dysfunction in AD, we performed a transcriptome analysis of the pineal glands of AD model mice and compared them to those of normal mice. There were diverse protein-coding RNAs, long noncoding RNAs and circular RNAs with global change in the pineal glands of AD mouse model. The analyzed data reported in this study will be an important resource for future studies to elucidate the altered physiology of the pineal gland in AD. Wild type pineal gland versus 5xFAD pineal gland (four biological replicates each)松果体（pineal gland）可通过分泌褪黑素（melatonin）维持机体的昼夜节律。阿尔茨海默病（Alzheimer's disease, AD）是最常见的神经退行性疾病。目前已有大量研究观测到阿尔茨海默病患者的松果体存在功能损伤，但迄今为止尚无研究分析阿尔茨海默病患者松果体的转录组（transcriptome）。为构建阿尔茨海默病相关松果体功能障碍研究的基础资源，我们对AD模型小鼠的松果体开展了转录组分析，并将其与正常小鼠的松果体样本进行对比。AD模型小鼠的松果体中存在大量发生全局表达改变的编码蛋白RNA（protein-coding RNAs）、长链非编码RNA（long noncoding RNAs）及环状RNA（circular RNAs）。本研究发布的分析数据，将为未来阐明阿尔茨海默病中松果体生理功能异常的相关研究提供重要科研资源。本数据集包含野生型（wild type）松果体与5xFAD松果体样本，每组各设4个生物学重复（biological replicates）。