five

Gene expression analysis on the immortalized human mesothelial cell lines with different morphologies.

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128788
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Establishment of immortalized human omental mesothelial cell lines (HOMCs) resulted in cloning three sublines (HOMC-B1, A4 and D4) with different morphologies. HOMC-B1 forms an epithelial-like monolayer. HOMC-A4 shows spindle-shaped morphology (storiform pattern). HOMC-D4 displayed an intermediate appearance. With the aim of exploring the key genes on decision of cellular morphology, gene expression of HOMC cell lines were analyzed along with conventional normal pleura-derived cell line, MeT-5A. Array analysis was performed with three HOMC cell lines with different morphology and human normal pleura transformant MeT-5A as reference cells.
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2021-10-27
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