Fiber Optic Theranostics (FOT): The interstitial fiber-optic needles for cancer sensing and therapy

<b>We investigate tumor detection by using the hypoxia-sensitive fluorescent fiber to realize the fast and accurate tumor recognition and diagnosis. We further perform the tumor treatment by exploiting the endogenous photothermal effect of the rare-earth-doped optical fibers, which are minimally intervened into the solid tumor. The suppression and eradication of tumor xenografts significantly validate the availability of the presented tumoricidal fiber. Our strategy opens horizons to inspire the design of optical fiber-mediated “plug and play” precise tumor theranostics, which may intrigue broader fields, such as fiber optics, materials, chemistry, medicine, and clinics.</b>