Transcriptional profiling of striatum from 6-month-old mice heterozygous knockout for 52 genes and corresponding wildtype control mice

As part of collaboration between the X. William Yang Lab at UCLA and CHDI, a list of 52 genes that were implicated in Huntington's disease (HD) through various computational modeling efforts was compiled, and murine lines with heterozygous knockout of these genes were obtained from public repositories or newly created. Striatum was dissected from 6-month-old mice that were either heterozygous KO for one of 52 genes or the corresponding wildtype (WT) controls. Transcriptomic analysis (RNASeq) was performed. Overall design: RNASeq analysis was performed on samples from striatum of 6-month-old mice with heterozygous KO of one of 52 genes and corresponding WT controls. N = 2x8 per line (KO gene).