JunB involved in functional and structural integrity of the epidermo-pilosebaceous unit in the skin

Transcription factors ensure skin homeostasis via tight regulation of distinct resident stem cells. We have identified JunB, a member of the AP-1 transcription factor family, regulated epidermal stem cells and sebaceous glands through balancing proliferation and differentiation of progenitors and by suppressing lineage infidelity. These findings define an unprecedented role for JunB in epidermal-pilosebaceous stem cell homeostasis and its pathology.