Differential expression of miRNA in stretched rat alveolar epithelial cells

Cyclic stretch of alveoli is characteristic of mechanical ventilation, and is postulated to be partly responsible for the lung injury and inflammation in ventilator induced lung injury. We propose that miRNAs may regulate some of the stretch response and, therefore, hypothesized that miRNAs would be differentially expressed between stretched and unstretched rat alveolar epithelial cells (RAECs).肺泡周期性牵张是机械通气的特征性表现，且被认为是呼吸机诱导肺损伤（Ventilator Induced Lung Injury）引发肺损伤与炎症反应的部分致病因素。我们提出微小RNA（microRNAs，miRNAs）或可调控部分牵张应答反应，据此假设：经牵张处理与未牵张处理的大鼠肺泡上皮细胞（Rat Alveolar Epithelial Cells，RAECs）中，miRNAs的表达水平存在差异。