Transcriptome Analysis of Non-Human Primate Induced Pluripotent Stem Cell-Derived Cardiomyocytes in 2D Monolayer Culture versus 3D Engineered Heart Tissue
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=b81a2b334cabb95098b90811a9621469
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资源简介：
In this study, we utilized both monolayer culture (2D) and engineered heart tissue (EHT) (3D) with NHP iPSC-CMs, which served as surrogates of direct cell injection and cell patch in vivo during exposure to hypoxic conditions, and the outcomes were compared at the transcriptome level. We found the 3D EHT model was more sensitive to ischemic conditions and similar to the native in vivo myocardium in terms of cell-extracellular matrix/cell-cell interactions, energy metabolism, and paracrine signaling.
提供机构：
Stanford University School of Medicine
创建时间：
2022-02-20
