Description of simulation schemas.

aIn each schema, three two-locus interaction models (additive × additive, dominant × dominant and recessive × recessive) were evaluated.bORG, ORH, and ORGH denote the main effect for locus G, main effect for locus H, and their interaction effect, respectively. “√” indicates that the effect is present. “–” indicates that the effect is absent.cDisease prevalence (baseline penetrance).dFor Schemas 8 and 9, the interaction effect ORGH was increased from 1.0 to a value at which the power of the optimal metric achieved 100% at significance level 0.01.