Univariate and multivariate Cox analyses of OS in 370 patients with PC not undergoing surgery according to pre-treatment concentrations of plasma YKL-40, IL-6, serum CA 19.9, age, sex and stage.

HR = Hazard ratio. CI = Confidence interval. Stage is scored as IIB+III vs. IV. Hi, high concentration; Lo, low concentration.Multivariate 1: Dichotomized biomarkers. §Plasma YKL-40 was dichotomized (high vs. normal according to the age-corrected upper 95% percentage limit of YKL-40 in healthy subjects). §§Plasma IL-6 was dichotomized (high vs. normal according to 95% percentage limit of IL-6 in healthy subjects, i.e. cut-off 4.5 ng/l). §§§Serum CA 19.9 was dichotomized (high vs. normal according to the cut-off 37 kU/l).Multivariate 2: The biomarkers are log transformed (log base 2) i.e. hazards are for a twofold difference.