EBF1-mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential

Name: EBF1-mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential
Creator: Max Planck Institute of Immunobiology and Epigenetics
Published: 2022-02-20T00:00:00+08:00

干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录

造血干细胞

骨髓微环境

数据链接：

http://data.iscr.ac.cn/Article?id=e0ca2489f985fc264cfd542ca1b0bdab 数据链接链接失效反馈

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资源简介：

Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem and cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Ebf1-deficient MSCs have reduced mesenchymal lineage potential. Ebf1 deletion in Cxcl12-abundant reticular (CAR) cells and PDGFRÎ±+Sca1+CD45-CD31-Lin- (PÎ±S) cells in the bone marrow decreased the numbers of HSPCs and myeloid cells. EBF1 in the bone marrow niche regulates a transcriptional program that determines the functional interactions with HSCs and the long-term balance between the myeloid and lymphoid cell fates.

提供机构：

Max Planck Institute of Immunobiology and Epigenetics

创建时间：

2022-02-20