Comparison of mRNA profiles of AGO2 sufficent and deficient pancreatic tissue in the LSL KRASG12D mouse model of pancreatic cancer. Comparison of mRNA profiles of AGO2 sufficent and deficient pancreatic tissue in the LSL KRASG12D mouse model of pancreatic cancer

Purpose: The goals of this study are to compare NGS-derived transcripts to compare the expression of transcripts between AGO2 sufficent PDAC tissue and AGO2 deficient senescent PanINs in the mouse model Methods: mRNA profiles of 500 day-old AGO2+/+;KRASG12D;p48Cre and AGO2fl/fl;KRASG12D;p48Cre pancreatic tissue were generated in duplicates Results: mRNA transcripts were further analyzed using GSEA tools for mouse transcript quantitation Overall design: Pancreatic tissue mRNA profiles of AGO2+/+;KRASG12D;p48Cre and AGO2fl/fl;KRASG12D;p48Cre mice at 500-day time point were generated by deep sequencing.