STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer [mRNAseq_PDX]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE154909
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资源简介：
We characterized Gemcitabine resistant pancreatic cancer tumors and show that the co-amplification of RRM1 and STIM1 confers novel and independent properties to gemcitabine resistant cells. The upregulation of RRM1 drives gemcitabine resistance, while the amplification of STIM1 leads to increased cytosolic calcium upon stress, eliciting ER stress resistance and NFAT activation. We performed mRNAseq from vehicle or Gemcitabine and nab-Paclitaxel treated pancreatic cancer patient-derived xenografts.
创建时间：
2021-01-18
