A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis

A new population of dysfunctional astrocytes in the aging mouse hippocampus called autophagy-dysregulated astrocytes (APDAs) show impaired protein homeostasis and defective regulation of synapse formation and elimination and appear early in a mouse model of Alzheimer's disease. Overall design: Single cell RNA-seq of 2-year-old WT mouse brains, Six hippocampi were analyzed