Deacetylation of Sirt2 regulates PKM2 ubiquitination and its effect on liver glucose metabolism

In order to explore the effects of SIRT2 on the liver metabolic function of mice under metabolic stress, we constructed SIRT2 knockout mice. Comparative gene expression profiling analysis of RNA-seq data for wildtype and SIRT2 KO mice.为探究代谢应激状态下沉默信息调节因子2（SIRT2）对小鼠肝脏代谢功能的影响，本研究构建了SIRT2基因敲除小鼠，并对野生型（wildtype）与SIRT2敲除（KO）小鼠的RNA测序（RNA-seq）数据开展了比较基因表达谱分析。