Genome-wide occupancy of chromatin remodeller SMARCAL1 and BRG1 in human cells

In this study we report genome wide occupancy of SMARCAL1 and BRG1 in control HeLa cells. Our analysis showed binding of these two remodellers on DNA damage response gene, chromatin remodellers, cell cycle and apoptosis regulating genes. Chromatin immunoprecipitation of SMARCAL1 and BRG1 was done using polyclonal and monoclonal antibodies respectively and subjected to high-throughput next generation sequencing on illumine platform.