Exploring acupuncture mechanism in preconditioning of IRI

JJ group compared with the MX group, 703 differentially expressed genes were screened out, among which 542 were up-regulated and 161 genes were down-regulated; compared with DZ group, 1529 differentially expressed genes were screened, 1212 genes were up-regulated and 317 genes were down-regulated. KEGG Pathway analysis enriched the Wnt pathway, and screened 11 genes; among which 9 genes were up-regulated, including Wnt5b, Wnt9b, Wnt10b, Fzd2, Plch1, Plch2, dkkl1, Amer and Amer3, and 2 were down-regulated, including plcb1 and sapcd2. Rats were randomly divided into sham group(DZ), IRI group(MX), Jiaji group（JJ）, Neiguan group（NG）, Yanglingquan group(YL), Quchi group(QC). After 7 day’s pretreatment of acupuncture, MIRI model was replicated by ligation of the left anterior descending coronary artery in MX group and all acupuncture groups(n=4 respectively).