High gene expression of IL8 in peripheral blood mononuclear cells from bladder cancer patients is associated with nonresponders to atezolizumab. High gene expression of IL8 in peripheral blood mononuclear cells from bladder cancer patients is associated with nonresponders to atezolizumab

Elevated plasma interleukin-8 (IL8) has been associated with poor outcome to immune checkpoint blockade. Here we performed single cell RNAseq with peripheral blood mononuclear cells (PBMCs) of patients treated with atezolizumab (anti-PD-L1 mAb) from bladder cancer from a Phase II trial IMvigor210. We found that high IL8 gene expression is enriched in nonresponders to atezolizumab Overall design: Single-cell RNA-seq of baseline pretreatment PBMC samples from 10 cancer patients with 5 responders and 5 nonresponders. ------------------------------------ Authors state "The authors have submitted the Responder and NonResponder raw data files to EGA: EGAS00001004008". Authors state "The authors have submitted the Blood and Tumor raw data files to EGA: EGAS00001004230".