Histopathologic injury scores from kidneys of non transgenic and transgenic mice at 5–9 months of age.

Features consistent with a glomerulopathy found in Trpc6-HA wild type (419 and 421) and mutants P111Q (615, 616) and E896K (73a, 75a) transgenic mice are shown. HC: hypercellularity, SCL: sclerosis, MEM: thickened membranes. The total scores for all glomerular lesions found in each transgenic line is shown in the last column. For each genotype the number of adult mice analyzed is as follows: non transgenic mice: n = 9, transgenic 419 n = 10, 421 n = 7, 615 n = 11, 616 n = 12, 73a n = 11, 75a n = 7. Data are presented as mean +/− SEM.*; **; ***mean statistical significance using non transgenic as control group with a P value