Table_1_v1_High-Dose Tranexamic Acid in Patients Underwent Surgical Repair of Aortic Dissection Might Reduce Postoperative Blood Loss: A Cohort Analysis.docx

IntroductionWhile tranexamic acid (TXA) is widely used in patients with acute type A aortic dissection (ATAAD) who undergo surgical repair to reduce blood loss and transfusion requirement, the optimal dosage of TXA is unknown in these patients.Materials and MethodsThis was a retrospective cohort study that compared high-dose (>50 mg/kg) and low-dose TXA (≤50 mg/kg) in patients with ATAAD who underwent surgical repair. Propensity score matching (PSM) was performed between the two groups and results were analyzed in matched cases. The primary outcome was postoperative blood loss within 3 days after surgery. The secondary outcomes were total blood loss after surgery and perioperative blood transfusion, and safety outcomes were also assessed.ResultsThrough medical record screening, 529 patients were identified. After PSM, 196 patients in the high-dose group and 196 patients in the low-dose group were matched and included in the final analysis. Postoperative blood loss in 3 days after surgery was 940 mL (710–1,010 mL) in the low-dose group and 695 mL (620–860 mL) in the high-dose group. The difference was statistically significant (P

引言：尽管氨甲环酸（TXA）在急性A型主动脉夹层（ATAAD）患者接受手术修复以减少出血和输血需求时得到广泛应用，但此类患者中TXA的最佳剂量尚不明确。材料与方法：本研究是一项回顾性队列研究，比较了接受手术修复的ATAAD患者中高剂量（>50mg/kg）与低剂量TXA（≤50mg/kg）的疗效。对两组患者进行了倾向性评分匹配（PSM），并在匹配的病例中分析了结果。主要结局指标为术后3天内的出血量。次要结局指标包括术后总出血量和围术期输血，同时亦评估了安全性结局。结果：通过病历筛选，确定了529名患者。经过PSM后，高剂量组和低剂量组各有196名患者被匹配并纳入最终分析。术后3天内的出血量在低剂量组为940mL（710–1,010mL），在高剂量组为695mL（620–860mL）。差异具有统计学意义（P