Parameter estimates for cell-type specific infectivity.

Measurements on viral load and cell-type specific infection based on single-cell RNA sequencing data of SARS-CoV-2 infected ALI-cultures of human bronchial airway epithelium [27] were analyzed using the model shown in Eqs (3) and (4) and Fig 2A. The best parameter combination and the 90%-credible intervals (CrI) in the last generation of an Approximation Bayesian Computation approach (pyABC) after 50 generations are shown (*values from literature). Epithelial turnover dynamics were parameterized according to the best estimate shown in Table 1 (see also S2 Fig).