Wood cookstove use is associated with gastric cancer in Central America, modified by the CYP1B1 genotype rs1800440, and independent of H. pylori cagA serostatus

Wood cookstove use is associated with gastric cancer in Central America, modified by the CYP1B1 genotype rs1800440, and independent of H. pylori cagA serostatus.

We conducted a population-based, case-control study (814 incident cases, 1,049 controls) in rural Honduras, a high-incidence region with a homogeneous diet and endemic H. pylori infection, primarily with the high-risk CagA genotype. We investigated factors including wood cookstove use, H. pylori CagA serostatus, and 15 variants from 7 metabolizing genes, and the interactions between wood stove use and the genetic variants.