Core Scaffold-Inspired Stereoselective Synthesis of Spiropyrazolones via an Organocatalytic Michael/Cyclization Sequence
收藏Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Core_Scaffold_Inspired_Stereoselective_Synthesis_of_Spiropyrazolones_via_an_Organocatalytic_Michael_Cyclization_Sequence/2468197
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资源简介：
Herein, the organocatalytic asymmetric Michael/cyclization sequence of α-isothiocyanato imides and esters with a variety of unsaturated pyrazolones is presented, in general, affording functionalized spiropyrazolones containing three contiguous stereogenic centers in high levels of diastereo- and enantioselectivity (up to 20:1 dr and 99% ee). Moreover, the current protocol provides a highly efficient and convenient strategy that allows rapid enantioselective construction of diversely spiropyrazolone skeletons with high optical purity.
创建时间：
2016-02-20
