WP410 - Exercise-induced circadian regulation - Homo sapiens

Human genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianally regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianally regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianally regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.
Based on [Zambon et al, Genome Biol. 2003;4(10):R61](https://www.ncbi.nlm.nih.gov/pubmed/14519196).

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP410)