RNAseq of mRNA from splenic and hepatic CD8 T cell populations after resolved and during persistent AdV infection

We aimed at dissecting phenotype, functionality and regulation of antigen-specific hepatic and splenic CX3CR1-positive and hepatic CXCR6-positive CD8 T cells after resolved or during persistent viral infection of the liver. Overall design: Comparison of splenic and hepatic CD8 T cell populations in two infection models (n=3 for each sample group). For resolved infection, hepatic T cells were sorted into CXCR6 and CX3CR1 populations. For persistent infection, hepatic T cells were sorted into CXCR6 and CXCR6-CX3CR1 populations.