Granulin Loss of Function in Human Mature Brain Organoids Implicates Astrocytes in TDP-43 Pathology

NIAID Data Ecosystem2026-03-14 收录

神经退行性机制

TDP43蛋白病

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA925944 数据链接链接失效反馈

官方服务：

资源简介：

Bulk RNAseq from 4 weeks old GRN+/+ and GRN-/- mature brain organoids (mix of human iPSC-derived cortical-like neurons and astrocytes)

创建时间：

2023-01-20

Type I Interferon Signaling Mediates Microglial Dysfunction and Senescence in Human-Mouse Chimeric Brain Models of Down Syndrome and Alzheimer's Disease [single-cell RNA-seq]

神经退行性机制

小胶质细胞衰老

Microglia are critical for brain development and play a central role in Alzheimer's disease (AD) etiology. Down syndrome (DS), also known as trisomy 21, is the most common genetic origin of intellectu

NIAID Data Ecosystem10

APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition [bulk RNA-seq]

神经退行性机制

胶质细胞转录组学

The Christchurch mutation (R136S) on the APOE3 (E3S/S) gene is associated with attenuation of tau load and cognitive decline despite the presence of a causal PSEN1 mutation and high levels of amyloid

NIAID Data Ecosystem00

Gene Expression Responses to FUS, EWS, and TAF15 Reduction and Stress Granule Sequestration Analyses Identifies FET-Protein Non-Redundant Functions

FET蛋白功能比较

神经退行性机制

The FET family of proteins is composed of FUS/TLS, EWS/EWSR1, and TAF15 and possesses RNA- and DNA-binding capacities. The FET-proteins are involved in transcriptional regulation and RNA processing, a

Figshare2016-01-19 更新00

Determining transcriptome changes in whole spinal cord of GarsdelETAQ/+ adult onset mice [18-burgess-006]

神经退行性机制

转录组学分析

To determine transcriptome changes in spinal cord induced by the GarsdelETAQ mutation. How mutations in broadly expressed housekeeping genes lead to neurodegeneration in specific cell types remains un

NIAID Data Ecosystem10

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases V

神经退行性机制

小胶质细胞表型

Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent mol

NIAID Data Ecosystem00

Granulin Loss of Function in Human Mature Brain Organoids Implicates Astrocytes in TDP-43 Pathology

资源简介：

相关数据集