Transcriptome reprogramming via Tob2-promoted global mRNA turnover
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE149684
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资源简介：
We found that multilayered phosphorylation of human Tob2 modulates its PABP-binding ability to change global deadenylation and mRNA turnover, which in turn reprograms transcriptome to influence cell proliferation. Bromouridine-metabolic labeling pulse-chase RIP-seq approach was combined with time-course experiments to monitor mRNA decay across the transcriptome upon induced expression of human Tob2. Vector only was used as controls.
创建时间：
2020-08-26
