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SILAC pulse labeling in HGPS fibroblasts - WT samples

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NIAID Data Ecosystem2026-03-10 收录
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Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectrometry to investigate nuclear protein homeostasis in primary HGPS-derived cells.

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2017-07-07
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