A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.
收藏PubMed Central1995-08-15 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC41269/
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资源简介：
We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in the intron that generates an amino acid change that is essential for the recognition of the peptide by the anti-tumor cytotoxic T lymphocytes. This observation suggests that the T-cell-mediated surveillance of the integrity of the genome may extend to some intronic regions. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-08-15
