Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia

NIAID Data Ecosystem2026-03-11 收录

白血病分子机制

HOX基因功能

数据链接：

https://www.omicsdi.org/dataset/ega/EGAS00001003627 数据链接链接失效反馈

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资源简介：

Study EGAS00001003627EGA study EGAS00001003627

创建时间：

2019-05-20

Effect of ZFX shRNA mediated knockdown in the human AML cell line NOMO-1. Homo sapiens

白血病分子机制

基因功能敲降

Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) maintain the undifferentiated phenotype and proliferative capacity of their respective cells of origin, hematopoietic stem/proge

NIAID Data Ecosystem30

DataSheet_1_Novel Non-Coding Transcript in NR4A3 Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and NR4A3 Expression.docx

白血病分子机制

非编码RNA功能

NR4A3 is a key tumor suppressor in myeloid malignancy, mice lacking both NR4A1 and family member NR4A3 rapidly develop lethal acute myeloid leukemia (AML). We identified a long non-coding transcript i

NIAID Data Ecosystem20

Oncogenic roles of ARID5B in T-ALL. Oncogenic roles of ARID5B in T-ALL

白血病分子机制

癌症基因组数据

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem20

Genes regulated by Meis1 in murine Mll-AF9 leukemia cells. Mus musculus

白血病分子机制

基因靶向治疗

Leukemias with MLL-rearrangements are characterized by high expression of the homeo box gene MEIS1. In these studies, we knocked down Meis1 expression by shRNA lentivirus transduction in murine Mll-AF

NIAID Data Ecosystem20

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

白血病分子机制

增强子劫持与基因表达

Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in veryyoung children and has a poor outcome. The expected oncofusion between breakpointpartners (MNX1 and ETV6) has on

NIAID Data Ecosystem20

Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia

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