Enrichment of Vd1/3 T cells in tuberculosis

In this study, we used single-cell RNA sequencing to provide a high-resolution characterization of CD4-CD8- ?? T cells in peripheral blood across healthy Mtb-non-sensitized, healthy Mtb-sensitized, and TB disease pre-/post-treatment cohorts. We found persistent upregulation of an activated and cytotoxic gene signature in ?? T cells of TB disease compared to both healthy cohorts, largely mediated by an NK-like cytotoxic Vd1 and Vd3 subset that was enriched in TB disease, with a unique Vd3 TCR gene usage. .