Nanoparticle triggered regulated necrosis

Programmed cell death: regulated necrosis. During regulated necrosis, different stimuli are recognized or sensed by specific receptors on the cell surface or inside cells. The activation of the necrosome stimulates different signaling pathways leading to mitochondrial hyperpolarization, lysosomal membrane permeabilization, and generation of reactive oxygen species (ROS), leading to cellular disintegration. A recent study revealed that germanium nanoparticles trigger necrostatin-1-inhibitable cell death with a reduction of the mitochondrial membrane potential. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2513 CPTAC Assay Portal]

程序性细胞死亡：调控性坏死。在调控性坏死过程中，细胞表面或细胞内部特定受体识别或感知到不同的刺激。坏死体的激活激发不同的信号通路，导致线粒体超极化、溶酶体膜通透性增加以及活性氧（ROS）的生成，最终导致细胞解体。近期研究显示，锗纳米颗粒可引发可被坏死素-1抑制的细胞死亡，并伴随线粒体膜电位的降低。该通路上的蛋白质已有靶向检测方法，可通过[CPTAC检测门户](https://assays.cancer.gov/available_assays?wp_id=WP2513)获取。