Pathological conditions and injuries, their effects on adhesion and their correlations with CNV.

Columns: Condition: type of condition, injury or perturbation in clinical or experimental observations. Subject: human or animal. Adhesion: strength of adhesion (+ = normal, − = moderately impaired, − = severely impaired). Effects: RPE viability (+ = most RPE cells remain viable, − = some RPE cells die, − = most RPE cells die), CNV loci (− = no or low probability of initiation and progression, sub-RPE = Type 1, sub-retinal = Type 2, combined pattern = Type 3, * = no data presented/available). Simulation results (boldface words = model objects. CNV Type definitions: see Table 4 and Table 5. * = no data presented/available. See the Results and Discussion sections for details of simulation results).