Replication of wt and <i>ca</i> influenza H7N9 viruses in mice.^a

a BALB/c mice were inoculated i.n. with 106 CCID50 of the Ah01/H7N9 or Ah01/AA ca virus or phosphate-buffered saline (control). These animals were euthanized 3 days after inoculation. Virus titers in nasal turbinate, lung, and brain tissue were determined in MDCK cells. The geometric mean titer ± SD is indicated. b Significant differences in virus titer between wt Ah01/H7N9 virus and Ah01/AA ca virus in the nasal turbinate and lung of mice. c p<0.02 by Student’s t-test on log-transformed titers. d Lower limit of detection is 10 CCID50/g tissue. Replication of wt and ca influenza H7N9 viruses in mice.a