tetX LC cleaves target cell VAMP2

Tetanus toxin light chain (tetX LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from vesicle-associated membrane protein 2 (VAMP2). tetX LC is a zinc metalloprotease (Foran et al. 1994; Schiavo et al. 1992). VAMP2 is associated with the cytosolic face of the target cell synaptic vesicle and is required for vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks exocytosis and in vivo leads to a long-lasting spastic paralysis (Link et al. 1992).

破伤风毒素轻链（tetX LC）在靶细胞的细胞质中催化从囊泡相关膜蛋白2（VAMP2）中去除氨基末端肽段。tetX LC是一种锌金属蛋白酶（Foran等，1994年；Schiavo等，1992年）。VAMP2与靶细胞突触囊泡的细胞质面相关联，对于囊泡对接和胞吐作用是必需的。由肉毒毒素引起的其切割会阻断胞吐作用，并在体内导致持久的痉挛性麻痹（Link等，1992年）。