Genome-Wide Association Study of Plasma Lp(a) Levels Identifies Multiple Genes on Chromosome 6q. Homo sapiens

Plasma lipoprotein(a) (Lp[a]) level is an independent risk factor of cardiovascular disease that is under strong genetic control. We conducted a genome-wide association study (GWAS) of plasma Lp(a) in 386 members of a founder population that adheres to a communal lifestyle, proscribes cigarette smoking, and prepares and eats meals communally. We identified associations with 77 single nucleotide polymorphisms (SNPs) spanning 12.5 megabases (Mb) on chromosome 6q26-q27 that met criteria for genome-wide significance (p <= 1.3 x 10-7), and were within or flanking nine genes, including LPA. We show that variation in at least six genes in addition to LPA are significantly associated with Lp(a) levels independent of each other and of the kringle IV repeat polymorphism in the LPA gene. One novel SNP in intron 37 of the LPA gene was also associated with Lp(a) levels and carotid artery disease number in unrelated Caucasians (p = 7.3 x 10-12 and... (for more see dbGaP study page.)