Gene expression changes in REH following STAT3 pharmacological inhibition
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE179333
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STAT3 (Signal transducer and activator of transcription 3) expression is associated with with t(12;21) acute lymphoblastic leukaemia (ALL) and it is crucial for the survival of the t(12;21) ALL . Our study investigated the STAT3 regulated pathways and discovered a novel STAT3-TP53 axis in B-ALL. In order to determine the STAT3 regulated pathways in t(12;21) ALL cells, we performed RNAseq analysis on the Pre-B Acute Lymphoblastic Leukemia (ALL) cell line REH, treated with DMSO vehicle control in comparison to 50uM S3I-021, a specific STAT3 inhibitor Total cellular RNA was purified from DMSO and 50uM S3I-201 treated REH samples from three independent experiments
创建时间：
2024-01-31
