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Bulk RNA-seq of in vivo expanded and franformed human IgM-producing tumor cells

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NIAID Data Ecosystem2026-05-01 收录
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We are trying to quantify differences between the transformed in vivo-expanded cells and non-transformed ex vivo plasma cells isolated from paired donors. we observed strong enrichment for several pathways in EBV+IgM+ B cells including nuclear factor kappa B (NF𝛋B) activation and Myc targets. And, Genes associated with BCR-regulated pathways were upregulated in EBV+IgM+ B cells. Enriched hCD45+ in vivo expanded tranformed human B cells derived from NSG mice receiving human differentitated B cells

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2023-12-26
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