Mouse Dspp frameshift model of human dentinogenesis imperfecta
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资源简介：
Using CRISPR/Cas9, we generated a _Dspp_^−1fs^ mouse model by introducing a FLAG-tag followed by a single nucleotide deletion that translated 493 extraneous amino acids before termination. Developing incisors and/or molars from this mouse and a _Dspp_^P19L^ mouse were characterized by morphological assessment, bSEM, nanohardness testing, histological analysis, in situ hybridization and immunohistochemistry.
创建时间：
2021-10-23
