Causal associations of mood swings with preterm birth: a Mendelian randomization analysis

有关情绪波动和早产的数据有关情绪波动和 BMI 的数据有关情绪波动和高胆固醇的数据有关情绪波动和高血压的数据有关情绪波动和受教育年限的数据有关情绪波动和吸烟的数据有关情绪波动和 T2DM 的数据有关 BMI 和早产的数据有关高胆固醇和早产的数据有关催眠和早产的数据有关受教育年限和早产的数据有关吸烟和早产的数据有关 T2DM 的早产数据Abstract:Background: Mood swings is associated with an elevated risk of preterm birth. However, the causal relationships between them still remain unclear. Methods: We performed a 2-sample mendelian randomization (MR) analysis to clarify the association between mood swings and preterm birth. To investigate the proportion mediated by recognized risk factors, we applied two-step MR mediation analyses. Three regression methods were used in MR analyses and using IVW as main method. Results: The MR analysis included 373,733 individuals with data on mood swings and 204913 participants with data on preterm birth. The results demonstrated significant causal effects of mood swings on preterm birth (OR=1.761,95% CI 1.151, 2.692). Further mediation analysis indicated hypertension (7.283%, 95 % CI: 0.387%–15.394 %) and high cholesterol (5.012%, 95% CI: 1.302%-8.613%) may mediate the causal pathways from mood swings to preterm. Conclusion: Mood swings has a notable causal impact on preterm birth, partly mediated by hypertension and high cholesterol.