A regulated RNA binding protein also possesses aconitase activity.
收藏PubMed Central1991-11-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC52877/
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资源简介：
A clone for the iron-responsive element (IRE)-binding protein (IRE-BP) has been transfected and expressed in mouse fibroblasts. The IRE-BP gene product binds IREs with high affinity and specificity. Amino acid alignments reveal that the IRE-BP is 30% identical to mitochondrial aconitase. The 18 active site residues of mitochondrial aconitase are identical to those in the IRE-BP, suggesting that the IRE-BP may possess aconitase activity. After purification of native IRE-BP and immunoaffinity purification of transfected and expressed IRE-BP, we demonstrate that the purified IRE-BP has aconitase activity. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1991-11-15
