Supplementary Material for: Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition

End-stage renal disease (ESRD) is common, costly, and it results from
progressive chronic kidney disease (CKD). ESRD claims many lives every
year. It is increasingly recognized that episodes of acute kidney injury
(AKI) predispose to the future development of CKD and ESRD. While our
understanding of the pathophysiology of the AKI to CKD transition is
improving, there are no validated therapeutic strategies to prevent this
transition. In this review, we summarize the recent progress made in
defining the cellular and molecular events underlying the AKI to CKD
transition and highlight potential therapeutic targets and strategies to
reduce the incidence of CKD following AKI.