Supplementary Material for: Association of Two Neonatal Encephalopathy Scores with Neurophysiology in Newborns with Suspected Hypoxic Ischemic Encephalopathy

Background/Objective: Severity of hypoxic-ischemic encephalopathy (HIE) is traditionally assessed by neurologic exam; however, electroencephalography (EEG) is a more standardized, reproducible measure of NE. We aimed to compare two numeric NE scores with neurophysiological measures of encephalopathy, to describe EEG patterns in newborns with low NE scores, and to assess evolution of NE scores within 6 hours after birth. Study Design/Methods: We retrospectively analyzed associations between two NE scores, aEEG, and cEEG in 321 newborns in a 14-center collaborative NE Registry. Results: There was a significant association between both NE scores and aEEG/cEEG (p1 hour of age. aEEG/cEEG may be particularly useful for identifying more substantial NE warranting TH treatment in newborns with mild NE by exam. Data from this study support standardized use of neurophysiology in evaluating asphyxiated, encephalopathic newborns.