Definition of the host susceptibility and strain virulence scenarios.

Scenarios S1 and S2 differ from the reference scenario S0 by their respectively low and high macrophage permissiveness. Scenarios S1S2 correspond to 19 intermediate scenarios (including S0) obtained by gradually varying the following parameter values: excretion rate (), macrophage infection rate () and phagocytosis rate (). Scenarios SB and SA differ from the reference scenario S0 by their cytokine synthesis capacities: scenario SB promotes antiviral over immuno-modulatory cytokine synthesis, and vice versa for scenario SA. Scenarios SBSA correspond to 19 intermediate scenarios (including S0) obtained by varying gradually the synthesis rates of the following cytokines: the innate antiviral cytokines and (both ); the immuno-regulatory cytokines ( & ), ( & ) and (). Low/high susceptibility and virulence levels correspond to scenarios with low/high macrophage permissiveness (S1/S2) and scenarios which promote the antiviral/immuno-modulatory cytokine synthesis (SB/SA). The parameter values corresponding to the reference scenario are in boldface.
Definition of the host susceptibility and strain virulence scenarios.